David R. Liu

@[email protected]
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Professor at Harvard University, the Broad Institute, and HHMI. Our lab integrates chemistry and evolution to illuminate biology and enable new therapeutics.
About meProfessor at Harvard University, the Broad Institute, and HHMI. Our lab integrates chemistry and evolution to illuminate biology and enable new therapeutics.
Websitehttps://liugroup.us
Twitter@davidrliu
David R. LiuJan 31, 2023

RT @[email protected]

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 https://www.nature.com/articles/s41467-023-35919-0

πŸ¦πŸ”—: https://twitter.com/ChemistryNews/status/1615336654264492038

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 - Nature Communications

Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci.

Nature
David R. LiuJan 26, 2023
Rest in peace, Orion (2003-2023). Thank you for 20 years of love, warmth, and snarkiness. πŸ™
David R. LiuJan 19, 2023

RT @[email protected]

A decade ago, 101 donors to a @[email protected] crowdfunding campaign made possible our first experiment: testing the therapeutic small molecule anle138b in mice with the same mutation Sonia inherited.

The final results: https://doi.org/10.1128/jvi.01672-22

Reflections on lessons learned πŸ‘‡

πŸ¦πŸ”—: https://twitter.com/cureffi/status/1616029036123136000

David R. LiuJan 16, 2023

RT @[email protected]

"I refuse to accept the view that mankind is so tragically bound to the starless midnight of racism and war."

Watch Martin Luther King Jr.'s Nobel Peace Prize speech, where he accepted the award on behalf of the American civil rights movement: https://bit.ly/2IBQvD4

#MLKDay

πŸ¦πŸ”—: https://twitter.com/NobelPrize/status/1614941852662104066

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.

NobelPrize.org
David R. LiuJan 13, 2023

RT @[email protected]

Base editing protects the heart. πŸ’•

Activation of CaMKIIΞ΄ causes tissue damage after heart attack.

Base editor, delivered via AAV9, removes oxidative sites in CaMKIIΞ΄; helps mice recover after severe damage. 4.4-fold drop in oxidized CaMKII after edits.

https://www.science.org/doi/10.1126/science.ade1105

πŸ¦πŸ”—: https://twitter.com/NikoMcCarty/status/1613660352910331906

David R. LiuJan 11, 2023

So much to say about Chris Walsh, beyond his remarkable productivity and his impact on our understanding of enzymes. Chris stepped up in countless ways to serveβ€”not because he sought to lead, but because he worked to make our community better using his widely admired wisdom.πŸ™

RT @[email protected]

RIP Chris Walsh

πŸ¦πŸ”—: https://twitter.com/CarolynBertozzi/status/1612995038866468866

Carolyn Bertozzi on Twitter

β€œRIP Chris Walsh”

Twitter
David R. LiuJan 11, 2023

RT @[email protected]

On behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.

πŸ¦πŸ”—: https://twitter.com/SchreiberStuart/status/1612890433729794072

Stuart Schreiber on Twitter

β€œOn behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.”

Twitter
David R. LiuJan 4, 2023

RT @[email protected]

We’re thrilled to announce the appointment of Nagesh Mahanthappa, PhD, as Executive Chair. Nagesh is an experienced biotech entrepreneur and will be an invaluable addition to our team as we advance our pipeline toward the clinic. Welcome to the Exo family! https://bit.ly/3X6eKhG

πŸ¦πŸ”—: https://twitter.com/ExoTherapeutics/status/1610625677488803845

David R. LiuDec 30, 2022

RT @[email protected]

#PublicationFridayπŸ“š In this 2020 publication, @[email protected], @[email protected], and Andrew Anzalone breaks down #CRISPR #genome editing agents as well as their strengths, limitations, and opportunities for future #clinical use https://pubmed.ncbi.nlm.nih.gov/32572269/

πŸ¦πŸ”—: https://twitter.com/somaticediting/status/1608840336796680224

Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors - PubMed

The development of new CRISPR-Cas genome editing tools continues to drive major advances in the life sciences. Four classes of CRISPR-Cas-derived genome editing agents-nucleases, base editors, transposases/recombinases and prime editors-are currently available for modifying genomes in experimental s …

PubMed
David R. LiuDec 25, 2022
It started in an eyebrow-raising way, but I think synthetic organic chemistry exams are safe from #ChatGPT, for now.
But note how good ChatGPT is at its primary talent: bullshitting.