David R. Liu

@davidrliu@mstdn.science
1.1K Followers
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95 Posts
Professor at Harvard University, the Broad Institute, and HHMI. Our lab integrates chemistry and evolution to illuminate biology and enable new therapeutics.
About meProfessor at Harvard University, the Broad Institute, and HHMI. Our lab integrates chemistry and evolution to illuminate biology and enable new therapeutics.
Websitehttps://liugroup.us
Twitter@davidrliu
David R. LiuJan 31, 2023

RT @ChemistryNews@twitter.com

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 https://www.nature.com/articles/s41467-023-35919-0

🐦🔗: https://twitter.com/ChemistryNews/status/1615336654264492038

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 - Nature Communications

Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci.

Nature
David R. LiuJan 26, 2023
Rest in peace, Orion (2003-2023). Thank you for 20 years of love, warmth, and snarkiness. 🙏
David R. LiuJan 19, 2023

RT @cureffi@twitter.com

A decade ago, 101 donors to a @lets_experiment@twitter.com crowdfunding campaign made possible our first experiment: testing the therapeutic small molecule anle138b in mice with the same mutation Sonia inherited.

The final results: https://doi.org/10.1128/jvi.01672-22

Reflections on lessons learned 👇

🐦🔗: https://twitter.com/cureffi/status/1616029036123136000

David R. LiuJan 16, 2023

RT @NobelPrize@twitter.com

"I refuse to accept the view that mankind is so tragically bound to the starless midnight of racism and war."

Watch Martin Luther King Jr.'s Nobel Peace Prize speech, where he accepted the award on behalf of the American civil rights movement: https://bit.ly/2IBQvD4

#MLKDay

🐦🔗: https://twitter.com/NobelPrize/status/1614941852662104066

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.

NobelPrize.org
David R. LiuJan 16, 2023

RT @Transactivator@twitter.com

Happy to share our latest paper on a broad new application of CRISPR for treatment of heart disease. Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease https://www.science.org/doi/10.1126/science.ade1105#.Y8Q9xNAXKK8.twitter @UTSWNews@twitter.com

🐦🔗: https://twitter.com/Transactivator/status/1614682735959744512

David R. LiuJan 13, 2023

RT @NikoMcCarty@twitter.com

Base editing protects the heart. 💕

Activation of CaMKIIδ causes tissue damage after heart attack.

Base editor, delivered via AAV9, removes oxidative sites in CaMKIIδ; helps mice recover after severe damage. 4.4-fold drop in oxidized CaMKII after edits.

https://www.science.org/doi/10.1126/science.ade1105

🐦🔗: https://twitter.com/NikoMcCarty/status/1613660352910331906

David R. LiuJan 11, 2023

So much to say about Chris Walsh, beyond his remarkable productivity and his impact on our understanding of enzymes. Chris stepped up in countless ways to serve—not because he sought to lead, but because he worked to make our community better using his widely admired wisdom.🙏

RT @CarolynBertozzi@twitter.com

RIP Chris Walsh

🐦🔗: https://twitter.com/CarolynBertozzi/status/1612995038866468866

Carolyn Bertozzi on Twitter

“RIP Chris Walsh”

Twitter
Show threadDavid R. LiuJan 11, 2023
Yoshi, you will be sorely missed.
I remember Yoshi stopping by my office at 5 am one morning when I was an assistant professor, praising me for my work ethic. I clarified that I had just landed on the red eye flight. Awkward pause. Grinning, he replied “I’m still proud of you.”❤️
David R. LiuJan 11, 2023

RT @SchreiberStuart@twitter.com

On behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.

🐦🔗: https://twitter.com/SchreiberStuart/status/1612890433729794072

Stuart Schreiber on Twitter

“On behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.”

Twitter
David R. LiuJan 9, 2023

RT @zhaoweiasu@twitter.com

1. The 1st $PRME corporate presentation:
https://investors.primemedicine.com/static-files/caee8230-5983-4f07-819b-9530a06a0323
Exciting advancements across all fronts!
➡️New preclinical data in FA and CF
➡️No detected OT
➡️New LNP and AAV mice data
➡️PASSIGE
➡️1st DC Q1 23.
➡️pegRNA patent expected Q1 23
➡️strategic collaboration coming

🐦🔗: https://twitter.com/zhaoweiasu/status/1612510781316403200