New preprint from the lab! Decoding working memory information from persistent and activity-silent neurons in the primate prefrontal cortex.
| Location | Nashville, TN, USA |
| Lab Page | https://lab.vanderbilt.edu/constantinidis-lab/home/ |
| Pronouns | he/ο/他 |
Christos Constantinidis ✅
@c_constan
- 1.3K Followers
- 780 Following
- 146 Posts
Professor of Biomedical Engineering and Neuroscience. Neural basis of cognitive functions, cognitive development/plasticity, deep brain stimulation
New paper from the lab:
Neuronal selectivity for stimulus information determines prefrontal LFP gamma power regardless of task execution
Neuronal selectivity for stimulus information determines prefrontal LFP gamma power regardless of task execution - Communications Biology
Electrophysiological recordings in male rhesus monkeys shows that neuronal selectivity for stimulus information determines prefrontal LFP gamma power regardless of task execution
A milestone for the lab, today. The FDA has granted us approval to test our pattern of intermittent, cholinergic Deep Brain Stimulation, in human patients. It has been a privilege to be part of a wonderful team in this voyage. Next stop, IRB approval!
#neuroscience
#bme
#neuroscience
#bme
Strength of excitatory inputs to layer 3 pyramidal neurons during synaptic pruning in the monkey prefrontal cortex: Relevance for the pathogenesis of schizophrenia
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)00047-1/fulltext
Prioritizing flexible working memory representations through retrospective attentional strengthening
https://www.sciencedirect.com/science/article/pii/S1053811923000502
Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia
Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia
In this chapter, I review studies in nonhuman primates that emulate the circuit failure in prefrontal cortex responsible for working memory and cognitive control deficits in schizophrenia. These studies have characterized how synaptic malfunction, typically induced...