A spoonful of sugar #7 🍬
Long pentraxins (PTX3) are domains located in the extracellular regions of selected adhesion GPCRs. An octameric assembly of PTX3 was recently resolved by cryo-EM and AF (https://doi.org/10.1073/pnas.2208144119) and it is available in PDB 7ZL1.
GlcNAc-scanning confirms occupancy of all N-glycosylation sites. Accordingly we restored the glycoprotein in 'one-shot' by selecting an FA2G2S2 form, in line with the glycoproteomics profile.



