Olaya Rendueles

@[email protected]
99 Followers
61 Following
25 Posts
Microbiologist interested in ecology & evolution
KeywordsCapsule, HGT, phages
PositionResearch associate @ Institut Pasteur & CNRS
Olaya RenduelesApr 20, 2023
Hi everyone,
We're looking forward to Session 4 of #KlebClub2023 on 25th April 9AM EST next week!
We will have a keynote from @jrpenades, followed by research talks by @wenwenlow from
@imperialcollege @NUSingapore, Nathalie Chen from @PittTweet
Olaya RenduelesApr 17, 2023

Happy monday friends!😀
Join us this week at Session 3 of #KlebClub2023

This tuesday, we'll have a keynote from @DariaVanTyne from @PittTweet, and research talks by @BettinaCheung from @NorthwesternU and Xueting Huang from Tsinghua U.

Register for free: https://sites.google.com/view/klebclub/home

KlebClub

Keynote Speakers for #KlebClub2023

Olaya RenduelesApr 11, 2023

Session 2 of #KlebClub will be airing in less than 24h!
Keynote from Richard Strugnell followed by research talks by Anirudh Desikahn and Ben Yezina .
Register for FREE (link in the picture below)

(Make sure you noticed the hour!)

Olaya RenduelesApr 7, 2023
Here the full line up of #KlebClub23!!
Olaya RenduelesApr 4, 2023
Akos T KovacsApr 4, 2023
RT @AlvSanMillan
New preprint from the lab! Ever wondered how successful associations between plasmids and bacteria emerge? Work led by the amazing @AidaAdelValle and @LauraToribioC with great collaborators, Carles Ubeda @RafaMCanton @epcrocha and @penamiller
https://www.biorxiv.org/content/10.1101/2023.04.03.535338v1
Olaya RenduelesApr 4, 2023
Christian KostApr 4, 2023
RT @SchiestlFlorian
A PostDoc position in Chemical Ecology is available in my lab, see https://t.uzh.ch/1sO
Please re-tweet to anyone potentially interested in the job!
Olaya RenduelesApr 4, 2023

Join us today for Session 1 of the Klebsiella Seminar Series (April 4th 9AM EST)! We are looking forward to awesome #Klebsiella Science in a few hours..

#KlebClub23

Still time to register

Olaya RenduelesApr 4, 2023
New publication from the lab!
We coevolved a phage-producing + phage-sensitive strain and tested the different phage resistance mechanisms, their emergence and their dynamics.
Unexpectedly, new lysogens are unstable and undergo excessive death rate during expo growth.
Other mechanisms of resistance like receptor (capsule) loss are fitter in short evolution times, but later, clones with receptor modifications or displaying phenotypic resistance are fitter.
https://doi.org/10.7554/eLife.83479
Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies

eLife
Show threadOlaya RenduelesMar 13, 2023

We speculate that when the capsule is added (exogenously) to a culture, it can bind antimicrobial peptides (AMPs).
Such sequestration titers AMPs in the media, effectively diluting it & ⤴️⤴️ tolerance, as more compound is required to obtain the same killing effect.

But when the capsule is bound to the cell surface (native form), it facilitates the entry of the AMPs as it retains AMPs near the cell surface where it can easily bind to the LPS, & ⤴️⤴️ susceptibility.

Olaya RenduelesMar 13, 2023

Check out our new manuscript on the role of the capsule in #resistance against polymyxins in #Klebsiella

We tested the MIC, growth @ sub-MIC [] & death rate of all non-capsulated mutants against 6 antibiotics including polymyxin B and last-resort colistin.

*The capsule certainly did not protect against antibiotics*

In fact, it REDUCED the MIC when cells were treated with polymyxins

https://doi.org/10.1128/aac.00127-23