Simon Mitchell

@[email protected]
41 Followers
91 Following
14 Posts
Senior lecturer in cancer research | BSMS - University of Sussex
| UKRI Future Leaders Fellow | Leukaemia UK John Goldman Fellow | Systems Biologist. He/him
Websitehttp://www.mitchell.science
PronounsHe/Him
ORCIDhttps://orcid.org/0000-0003-1091-6349
Scholarhttps://scholar.google.com/citations?user=lsKnTVoAAAAJ&hl=en&oi=ao
Simon MitchellApr 17, 2023
Pedro MendesApr 14, 2023

Congratulations Dr. Joseph Masison!

Very happy for Joe, who successfully defended his thesis "Computational Modeling of Duodenal Iron Metabolism"

Now he's on to complete the medical studies and end up with an MD-PhD degree.

Simon MitchellApr 17, 2023
Thomas A Caswell Apr 14, 2023

The Simons Foundation's Math and Physical Sciences division has just announced a new funding opportunity for scientific software-oriented researchers: The Scientific Software Research Faculty Award.

https://www.simonsfoundation.org/grant/scientific-software-research-faculty-award/

The award is a 5 year grant that provides 50% salary support for applicants to begin new Research Professor positions in scientific domain departments, currently limited to the physical sciences (physics, astronomy, mathematics).

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This is an amazing looking!

Scientific Software Research Faculty Award

Scientific Software Research Faculty Award on Simons Foundation

Simons Foundation
Simon MitchellApr 17, 2023
Martin JohnssonApr 11, 2023

Postdoc positions at our department at SLU. Come work with me (among others), do cool genomic prediction and population genomics research, mix data and models, in an animal genetics and breeding context. Apply at the link.

https://www.slu.se/en/about-slu/work-at-slu/jobs-vacancies/?rmpage=job&rmjob=8241&rmlang=UK​

Posting this again. I appreciate help with spreading the news.

#AnimalGenetics #AnimalBreeding #genomics #genetics

Jobs and vacancies at SLU. | slu.se

Jobs and vacancies at SLU. Read more about each job by clicking the job title. Please, follow the instructions closely when applying.

SLU.SE
Show threadSimon MitchellFeb 3, 2023
We hope this is a foundation for using systems biology to get the right drugs into the right patients (stay tuned)!
Thanks to the dream team: Ielyaas Cloete, Chris Pepper, Andrea Pepper, Martin Dyer and team + Meike Vogler.
Leukaemia UK and the UKRI FLF for funding.
Show threadSimon MitchellFeb 3, 2023
Finally, we wondered if we could predict how drugs combine, and found that some cells are predicted to respond synergistically to combinations of BH3-mimetics. We tested this exciting prediction with new experiments in the lab and were so happy to see the same result.
Show threadSimon MitchellFeb 3, 2023
We found the exact same approach works with a library of cell lines, that all respond differently to BH3-mimetics.
Simulations gave accurate predictions of the which is the right drug for the right DLBCL cell line. Predictions get even better when we consider mutations.
Show threadSimon MitchellFeb 3, 2023
A: Yes!
We used initial conditions from IPs and Co-IPs. We modelled cell-to-cell variability, which we measured before (https://pnas.org/doi/10.1073/pnas.1715639115). Simulations correctly predicted the most effective drugs.
Okay, so it works with one cell line, but they all respond so differently!?
Show threadSimon MitchellFeb 3, 2023
A: Sadly not with existing models of apoptosis :(
So Ielyaas, thanks to many chats with experts in apoptotsis, built a math model focusing on the the mitochondrial membrane and its complex interaction network.
First test: can we predict how a cell line responds to drugs?
Show threadSimon MitchellFeb 3, 2023
The work was inspired by a great paper from Martin Dyer's group in Leicester.
(https://haematologica.org/article/view/9988) where they show that response to BH3-mimetics is not as simple as more MCL1=better response to MCL1-targeting inhibitors. But in fact a complex interaction network is at play.
Q: Can we model this?
Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma | Haematologica

Simon MitchellFeb 3, 2023

Excited to share our latest preprint!
We show that you can predict how lymphoma cells will respond to drugs that target apoptosis, using simulations.

Lead by Ielyaas Cloete + collaborators at Leicester + Frankfurt

↓Tutorial Below↓

https://doi.org/10.1101/2023.02.01.526592

#LeukaemiaUK #UKRIFLF