MPI für Molekulare Genetik

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The Max Planck Institute for Molecular Genetics in #Berlin. We want to understand how the genome functions and how it is regulated, especially during embryonic development & disease.

A characteristic feature of our work is the combination of experimental & computational methods. We use numerous model systems, high-throughput & automated procedures. For data analysis & interpretation we use the tools that bioinformatics provide.

Interested in becoming a PhD student? Check out our #IMPRS!

Websitehttps://www.molgen.mpg.de
Grad Schoolhttp://www.molgen.mpg.de/IMPRS
Imprinthttps://www.molgen.mpg.de/impressum
We are looking for motivated #PhD students who want to work at the interface between molecular life sciences and computational sciences. #IMPRS #IMPRSBAC
Check out our projects and apply until Jan 7th, 2025! https://www.molgen.mpg.de/IMPRS/application
Application

The graduate program IMPRS for Biology And Computation (IMPRS-BAC) provides an education for students at the interface of molecular life sciences and computational sciences. This is based on perspective and supervision from both ends - experimental and computational - and suits students with degrees in molecular biology, biochemistry, mathematics, bioinformatics or any related areas. If you have a passion for epigenetics, bioinformatics, developmental biology, mathematics, sequence analysis, gene regulation, RNA biology, mechanobiology, protein biochemistry, stem cells and differentiation, statistics, molecular evolution or biophysics and want to work at the Max Planck Institute for Molecular Genetics or the Freie Universität Berlin - this is the program for you!

New paper by the lab of Aydan Bulut-Karslioglu in collaboration with Nicolas rivron at the IMBA Vienna now published in Cell! The team discovered that the mechanisms that control embryonic diapause also seem to be actionable in human stem cells and blastoids.
Read more: https://www.molgen.mpg.de/4770731/
Link to the publication: https://www.cell.com/cell/fulltext/S0092-8674(24)00977-2
Scientists Discover "Pause Button" in Human Development

Researchers at the Max Planck Institute for Molecular Genetics in Berlin (MPIMG) and the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences in Vienna have discovered a potential "pause button" in the earliest stages of human development. Whether humans can control the timing of their development has long been debated. The new study suggests that this “pause button” can be activated in human cells as well. The findings have significant implications for our understanding of early human life and may improve reproductive technologies.

Lucid Genomics, a spin-off company from the MPIMG and Charité has raised €1.3 million in pre-seed funding to fine tune its AI models for diagnostics and biomarker identification. Congrats to founders Hossein Moeinzadeh (left), Uirá Melo (second from left), and the entire team!
Read more: -> https://www.molgen.mpg.de/4764414
€1.3M pre-seed funding for Lucid Genomics

The Berlin-based start-up Lucid Genomics, a spin-off from the Max Planck Institute for Molecular Genetics and the Institute of Medical Genetics and Human Genetics at the Charité - Universitätsmedizin Berlin, has raised €1.3 million in pre-seed funding in a funding round led by Caesar Ventures, with support from BIF Partners, another.vc and the MPF Accelerator. The funds will be used to further expand their AI-Digital HealthTech Platform, which extracts all genomic information to improve diagnostics and drug discovery.

Congratulations to Yusuke Kijima from the Aktas lab on his Postdoc Fellowship by EMBO! Based on a recent discovery from the lab published in Nature, his project will investigate the molecular machinery of a novel pathway that silences transposon expression. Link to the publication in Nature: https://rdcu.be/dPySw
The lab of Denes Hnisz together with the Vingron Lab found chemical features in transcription factors (TFs) that encode submaximal transcriptional activity. The findings in Nature Cell Biology hint ways to create optimized TFs that could be used for regenerative therapies. --> https://www.molgen.mpg.de/4726976
Maximum Potential

Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to produce messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's lab at the MPIMG, has discovered that human transcription factors don't typically use their full potential to help transcribe mRNA. Instead, important protein regions within transcription factors encode chemical features that generate submaximal transcriptional activity. The findings, published in Nature Cell Biology, suggest simple ways to engineer natural transcription factor variants with elevated or “optimized” activity, with potential applications for regenerative therapy.

Congratulations to Alessa Ringel from the Mundlos Lab (left, with Judith Pirscher from the BMBF), who received the first "Major Groove" award during our 60th anniversary celebration! The prize will be given annually to an excellent PhD student at the MPIMG. --> https://www.molgen.mpg.de/4721644
60th anniversary of the MPIMG

Join us for the Long Night of Science on June 22! Experience an evening filled with talks, lab tours, a science pub quiz, and an exhibition. Most events will be in German, but we have some in English too. #LNDW
Full program 👉 https://www.molgen.mpg.de/4710459/lange-nacht-der-wissenschaften-2024
Lange Nacht der Wissenschaften in Berlin

Mit Vorträgen, Laborführungen und Mitmach-Experimenten lädt das Max-Planck-Institut für molekulare Genetik seine Gäste ein, zur Langen Nacht der Wissenschaften 2022 in die Welt der Genomforschung und Entwicklungsgenetik zu reisen.

The presence of extraembryonic cells in the developing gut has long puzzled scientists. In a new study in Nature Cell Biology, the Meissner lab now gained novel insight into the fate and molecular characteristics of these cells. Read more: https://www.molgen.mpg.de/4717564/
Link to publication: https://www.nature.com/articles/s41556-024-01431-w
Strange gut feeling

During development, extraembryonic cells contribute to the formation of structures outside of the embryo. The additional presence of these extraembryonic cells in the developing gut has long puzzled scientists. In a new study in Nature Cell Biology, Alexander Meissner’s lab now provides new insights into the developmental fate and molecular characteristics of these cells.

New results in Nature Structural and Molecular Biology from the lab of Aydan Bulut-Karslıoğlu show how pluripotent stem cells maintain their potential to differentiate into cells of the adult organism during embryonic dormancy. The scientists identified a mechanism that protects gene regulatory elements involved in maintaining pluripotency from being silenced during dormancy.

Read more: https://lnkd.in/ep2ZhV_d
Link to the publication: https://rdcu.be/dINnj

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Congratulations to Irene Talon from the Vallier Lab, who has recently been awarded a Postdoctoral Fellowship by EMBO! In her project Irene will study the principles governing the initiation of human organogenesis using pluripotent stem cells and organoids.