Mastodawn

LacknerLab May 19, 2025

What the f* is mycofactocin?
If you’ve ever wondered about the unusual cofactor – wonder no more. We’ve written up a review article for NPR covering its discovery, biosynthesis, and biological roles. Huge thanks to all co-authors who made this happen!
https://pubs.rsc.org/en/content/articlelanding/2025/np/d5np00012b

LacknerLab Mar 6, 2025

Great to see our article about the role of MftG in mycobacterial respiration highlighted in eLife: https://doi.org/10.7554/eLife.106286

Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.

eLife

LacknerLab Jan 30, 2025

Curious how tuberculosis-related mycobacteria process alcohol? We have identified a novel enzyme that couples ethanol metabolism to respiration in these organisms. Many thanks to all authors and our collaborators from the Papenfort and Vilotijevic labs!
https://doi.org/10.7554/eLife.97559.4

MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

The mftG gene, present in the majority of mycofactocin gene clusters, encodes an oxidoreductase that facilitates ethanol utilization by reoxidation of mycofactocins and channeling electrons towards the respiratory chain.

eLife

LacknerLab Jan 23, 2025

Universität Bayreuth Jan 23, 2025

🎉🏆 We are delighted to be ranked 8th among the best universities in Germany in the current StudyCheck ranking!✨

📖 Particularly praised:
⭐ Literature access
⭐ Course content
⭐ Lecturers

➡️ All details: https://www.uni-bayreuth.de/pressemitteilung/studycheck-ranking-2025
#UBT #UniBayreuth #Ranking #Studycheck

Universität Bayreuth erneut bei Studierenden unter den Top Ten

Studierende geben der Uni Bayreuth im Bewertungsportal Studycheck beste Noten. Sie landet auf Platz 8 der beliebtesten Universitäten Deutschlands und wird von 94 Prozent der Studierenden sogar weiterempfohlen.

LacknerLab Jan 17, 2025

Stephan Hacker Jan 17, 2025

Great paper by the group of Lars Jeuken in J. Biol. Chem. with first author Tijn van der Velden. Cytochrome bd of M. tuberculosis is RedOx-regulated through a disulfide with potential important implications for survival in the phagosome. Exciting insights into the biochemical activity, the substrate specificity and the activation of cytochrome bd as well as an insightful cryoEM structure to better understand the role of the critical, RedOx-regulated disulfide.
https://www.jbc.org/article/S0021-9258(24)02596-1/fulltext