@NicoleCRust @albertcardona @matthewcobb
One of the things I've been struggling with recently is how the vast majority of papers (including most or arguably all of mine) don't propose an idea that could in principle get us closer to understanding how the brain does what it does. I have the feeling that there was this moment in time when people were coming up with tons of crazy theories. They were all wrong (probably) but it was exciting. Now we're just talking about how many dimensions a 'neural manifold' has and I just can't get excited about that (sorry manifold people). In my case, I think I've had a small handful of ideas that went in the direction I'd like neuroscience to be going in of proposing ideas that could scale to part of a full explanation of the brain, but I haven't pursued them because they were hard to define or get funding for. My resolution for 2023 is to focus more on those interesting questions and less on things that I think are easy to get published or get funding. For what it's worth, the biggest challenge to neuroscience I reckon is how it can operate in a stable way based on what seems to be a surprisingly unstable substrate (e.g. synaptic turnover). If I had a good idea about how to solve that problem, that's what I'd be working on.
Edited to add: I don't mean to criticise anyone's work! It's more a personal realisation that I've not been pursuing research directions that I believe could really lead to understanding the brain. On a metascience level, I think it's important that different people take very different approaches, most of which they will disagree on. If it's not like this, we won't make progress. My realisation is perhaps that I've been trying too hard to fit in and it's not working for me.