Researchers have identified a direct link between intestinal obstruction and behavior in Drosophila melanogaster, where the inability to excrete metabolic waste (meconium) prevents independent feeding and induces prolonged sleep.
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https://www.sflorg.com/2026/06/gen06092601.html
Gut-Brain Axis: Intestinal Influence on Behavior

A study on Drosophila reveals how intestinal blockages halt feeding and induce sleep, uncovering vital mechanisms of gut-brain communication.