Not sure when this happened, but I've just found out that At The Sign Of The Dragon, a really rather good SF&F specialist second-hand bookshop in Wigtown has closed, due to the death of the owner.
I only got to go there once, a couple of years ago. He had a shed in the garden for the non-SF&F stock, and then the garage and one room in his house (accessed through his kitchen!) were absolutely stuffed full of the SF&F books.
A real loss.