As tourists to sketchy places in Asia discovered, methanol poisoning is a real risk, even from large scale distillation. It is the quality control that matters. Illegal stills make quality control impossible, so legalisation and government certified testing can make it safe.

However, this ruling is not about alcohol, it is about dissolving Federal authority exercised via the trade and commerce clause of the Constitution.

The antidote to methanol is just ethanol.

If you find yourself drinking something untrustworthy you can at least cure yourself with a chaser of an equivalent amount of everclear.

https://en.wikipedia.org/wiki/Methanol_toxicity#Treatment