I can confirm Creative Cloud has added to my /etc/hosts file.

Adobe secretly modifies your hosts file for the stupidest reason: https://www.osnews.com/story/144737/adobe-secretly-modifies-your-hosts-file-for-the-stupidest-reason/

@marcedwards How is it being modified when /etc/hosts is owned by root? An after-install script run by the package manager?
@linuxandyarn @marcedwards At least on my machine, Adobe adds some items to /Library/PrivilegedHelperTools. These will have root access.