An interesting summary from the editor:

"AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction."

https://www.nature.com/articles/s41467-026-70942-x

#AlphaFold #AI #interactions

Experimental assessment of AI-based interactome mapping - Nature Communications

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

Nature