hswapnilAs we suspected
Thiazide induced hyponatremia is more seen in older women
JNO analysis from Sweden https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847235
Lars Mølgaard Saxhaug@hswapnil I only use it as an adjunct short term diuretic, and often stop it in those who use it for hypertension.
The age:sex interaction is interesting, what could be the cause?
The age:sex interaction is interesting, what could be the cause?
@loaddependent the clinical observations is that this is due to low protein diet (eg tea and toast) - low solute + reduced renal diluting ability = hyponatremia
But there’s genetics too https://www.nephjc.com/news/thiazide which hasn’t reported age/sex interactions
Thiazide induced hyponatremia, a detailed phenotypic and genotypic analysis — NephJC
Thiazide induced hyponatremia occurs in about 10% of people. Is there a genetic link? Does that genetic link give clues to the mechanism of thiazide induced hyponatremia? Find out in the next exciting edition of #NephJC