"The agency has come under massive, massive attack," he told the David Hearst Podcast.
"We have had 391 personnel killed. A few weeks ago, our main headquarters in Sheikh Jarrah was stormed, demolished and set on fire, with officials from the government and parliament expressing jubilation and even arguing over who should take credit.
"We have also faced a massive disinformation campaign. We have had legal cases and three laws passed to try to dismantle us. So yes, there is deep frustration and disappointment that a UN agency has been so blatantly crushed without real action from member states or the international community. The attack on us has taken place with total impunity," he added.
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Israel was admitted as a UN member state in 1949 on the condition that it recognise Resolution 194, affirming the "natural and legitimate right" of Palestinian refugees to return to their homes and receive compensation.
But Israel's campaign against Unrwa is aimed at undermining that right of return - a core issue in final status negotiations - as it is the only UN agency that recognises Palestinian refugees and their descendants.
However, Lazzarini stressed that even if the agency were dismantled, the status of Palestinian refugees would not be affected.
