geneslator: an R package for comprehensive gene identifier conversion and annotation

Motivation: High-throughput sequencing generates large gene lists, making data interpretation challenging. Accurate gene annotation and reliable conversion between identifiers (e.g., Gene symbols, Ensembl GeneIDs, Entrez GeneIDs) are essential for integrating datasets, conducting functional analyses, and enabling cross-species comparisons. Existing tools and databases facilitate annotation but often suffer from inconsistencies, missing mappings, and fragmented workflows, limiting reproducibility and interpretability. Results: To address these limitations, we developed geneslator, an R package that unifies gene identifier conversion, orthologs mapping, and pathway annotation across eight model organisms ( Homo sapiens , Mus musculus , Rattus norvegicus , Drosophila melanogaster , Danio rerio , Saccharomyces cerevisiae , Caenorhabditis elegans , Arabidopsis thaliana ). geneslator provides an up-to-date, precise, and coherent framework that preserves data integrity, enables cross-species analyses, and facilitates robust interpretation of gene function and regulation, outperforming state-of-the-art gene annotation tools. Availability: geneslator is available at https://github.com/knowmics-lab/geneslator ### Competing Interest Statement The authors have declared no competing interest. 2024/2026 Research Plan of University of Catania Pia.ce.ri (IMAGINE project)