Jack William Bell1d ago

#Health news relevant to me.

> Diabetes drug metformin affects the brain, study finds: Here’s how. https://thehill.com/policy/healthcare/5803682-diabetes-drug-metformin-brain-study/

So, yeah, it works in the liver. But now they know it also works in the brain and from that they may be able to derive new treatment protocols than the standard high-dose oral medication.

Show threadJack William Bell

In related news I went to the doctor yesterday for a regular checkup and they just called me with the test results: everything looks good and my A1C is down nearly to pre-diabetes levels and well under the 'concerning' 7% number.

#health #MountainLiving

Mar 27 at 6:10pmWeb
Show threadRoy1d ago
@jackwilliambell
That's great!
Show threadAlan Bellingham1d ago
@jackwilliambell I'm bemused that you in the US use different units and measurements, but FWIW I now have my long-term HbA1c level at 44 mmol/mol (aka ~6%), well into the good range
Show threadJack William Bell1d ago

@bellinghman

At one point my doctor asked if I wanted to try one of the newer diabetes drugs. I declined, saying, "Metformin is one of the most studied drugs in the world including long-term cohort studies. If it works for me I'm staying on it and avoiding finding out a drug makes you grow a third hand out of your forehead after using it for ten years."

My doctor laughed and agreed with me.

Show threadAlan Bellingham1d ago
@jackwilliambell I'm on Metformin, Gliclazide and Dapaglifozin. My recent tweak was dropping the Gliclazide from 3 tablets a day down to 2. I'm trying to gauge what effect it's having on my blood glucose levels, but the first week was when we were away in Croatia
Show threadJack William Bell1d ago

@bellinghman

Good luck. I'm leery about using more than 1 drug at a time because of something that happened to my grandfather nearly 50 years ago:

He was doing really badly and we were worried he'd entered his final decline. He was also taking something like 20 pills a day with more than 5 different drugs and the doctor wanted to prescribe more.

Then he was hospitalized and the attending physician reduced it to 3 drugs. At which point his health came roaring back!

Drug interactions are bad…

Show threadJack William Bell1d ago

@bellinghman

Note that I got the lucky DNA on the blood pressure front. I naturally have more good cholesterol and less of the bad and the nurses always make approving noises when taking my blood pressure.