Quick rules reminder: Indestructible doesn't stop sacrifice effects. Your Avacyn can't save your creatures from Grave Pact or Dictate of Erebos. Indestructible only prevents damage and 'destroy' effects.

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@GrimDeck

Also doesn't stop Exile effects, or -1/-1 counters.

@sapphire Good catch! Exile is the real boogeyman. I've seen too many new players think indestructible makes their stuff untouchable, then someone casts Path to Exile and reality sets in.