Psilocybin or Nicotine Patch for Smoking Cessation A Pilot Randomized Clinical Trial (Johnson, et al, 2026) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846155?resultClick=1 In this pilot randomized clinical trial, 1 dose of psilocybin with manualized CBT significantly increased long-term abstinence compared with nicotine patch treatment with CBT. Psilocybin abstinence rates were higher than typical treatments, suggesting promise for tobacco smoking cessation. #psychedelics #psilocybin #cognitivebehavioraltherapy #psychedelictherapy
Psilocybin or Nicotine Patch for Smoking Cessation

This pilot randomized clinical trial compares prolonged smoking abstinence rates in smokers receiving psilocybin with those receiving the nicotine patch with both groups receiving manualized smoking cessation cognitive behavioral therapy.