Red Dead Redemption 2. The cutscenes are too long and boring.
I gave up after accidentally doing things too many times. The hotkeys felt like an ever shifting mess and I got tired of constantly reloading after pressing the wrong one. It was a bummer because I loved the setting and overall feel of the game, just ran out of patience after so many times not knowing how to do the thing I wanted to do and half the time ending up doing something unintentionally violent.
Elite Dangerous has a zillion hotkeys as well but that feels more like gameplay and learning to operate a complicated ship. Accidentally wasting a heat sink with a wrong keypress is different from accidentally starting a fistfight with a random person when I meant to wave and say howdy partner