Red Dead Redemption 2. The cutscenes are too long and boring.
And some of them are unskippable.

I gave up after accidentally doing things too many times. The hotkeys felt like an ever shifting mess and I got tired of constantly reloading after pressing the wrong one. It was a bummer because I loved the setting and overall feel of the game, just ran out of patience after so many times not knowing how to do the thing I wanted to do and half the time ending up doing something unintentionally violent.

Elite Dangerous has a zillion hotkeys as well but that feels more like gameplay and learning to operate a complicated ship. Accidentally wasting a heat sink with a wrong keypress is different from accidentally starting a fistfight with a random person when I meant to wave and say howdy partner

Eeeh, the length of the cutscenes wasn’t really what put me off but rather the fact that I didn’t care about most of the people in them. I fact, I never got invested in any of the characters.

Their world building and dedication to creating complex systems are fantastic but Rockstar Games makes their characters so repulsive that I don’t enjoy being around them, much less advance whatever agenda they have. Same with GTA V (and presumably VI as well).

I agree. Rockstar makes truly impressive games, but I can’t get into them. The characters and stories have no redeeming qualities from what I could tell.
Any game with unskippable cutscenes instantly drops dead for me. It’s padding I don’t want to wade through.
This is the one for me as well. The gameplay is simply horrendous. Just getting on and off the horse was a chore in of itself.
Don’t forget to clean your horse off every few hours by brushing it in the same spot 3 times. Just… Why