Jo, no problem! Just use the proprietary drivers and vulcan, cuda etc. Just works
Especially with a recent card, like a 4060. Problematic are only the cards which are considered legacy by nvidia (I think older than the GTX 900 series), because they do not update their drivers for newer kernels. In these cases resorting to nouveau (in-kernel driver for nvidia cards) is your best bet, but you will not use the card’s full potential.