Source-Level Debugging of Compiler-Optimised Code: Ill-Posed, but Not Impossible, https://dl.acm.org/doi/10.1145/3689492.3690047. There's almost no research in this area so it's good to see someone thinking about some of the challenges. I'd like to have seen a discussion of undefined behavior, specifically, since there's a paradox where C programmers are most likely to use debuggers exactly in cases where UB is present, which poses fundamental challenges to source-level debugging.