Maybe there was a cure for human cancer, but it didn't work at all in mice.

https://lemmy.world/post/38336481

In the long run, using mice to test human medicines will result in selection pressure for humans whose physiology more and more closely resembles mice.
Mice, notorious for living in unclean conditions and being carriers of fleas and disease will definitely have a different set of evolved resistances and immunities to us. It’s pretty ludacris science believes them to be a good point of comparison.
It’s just an early testing phase, more of an “ok, this drug kind of did what we want in mice, and the mice didn’t explode. It’s time to move to the next stage of testing on something more human analogue, like a pig.”