Molecular glues induce degradation of proteins, but rational design remains challenging. A #Science study scan human proteins for CRBN-binding motifs, exploring hundreds of targets including non-canonical ones like VAV1. The study highlights the potential of hundreds of protein domains that could be used in future drug design campaigns, making it possible to target the ‘undruggable space’.

#drug #research #chemicalbiology

https://www.science.org/doi/10.1126/science.adt6736