1/8 Você sabia? A colibactina, uma toxina produzida por certas cepas de E. coli no intestino, pode danificar seu DNA e aumentar o risco de câncer colorretal. 😱 Mas a dieta influencia isso! Bora explorar como uma dieta à base de plantas pode proteger sua saúde. 🌱 #Veganismo #Saúde https://www.nature.com/articles/s41591-020-0908-2
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer - Nature Medicine

Identification of a DNA-damage signature induced by colibactin, a toxin expressed by some strains of Escherichia coli, is enriched in human colorectal cancers.

Nature
2/8 A colibactina é uma genotoxina com um anel ciclopropano reativo. 💥 Essa estrutura alquila o DNA, causando quebras de dupla hélice. Sua produção depende de bactérias E. coli pks+. A dieta molda o ambiente intestinal que ativa essa química perigosa. 🧪 #CiênciaVegana https://pubs.acs.org/doi/10.1021/acs.biochem.8b01023
3/8 Baixos níveis de ferro no intestino podem aumentar sua produção, enquanto altos níveis de ferro a diminuem. A inflamação intestinal pode promover o crescimento de cepas de E. coli que produzem colibactina, aumentando assim a exposição à toxina. Dietas ricas em carne podem influenciar esses fatores, mas a relação é complexa. 🚫 #VeganismoÉPrevenção https://pubmed.ncbi.nlm.nih.gov/37059096/
https://pmc.ncbi.nlm.nih.gov/articles/PMC5116714/
https://www.mdpi.com/2072-6651/13/5/346
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin - PubMed

The genotoxin colibactin produced by Escherichia coli is involved in the development of colorectal cancers. This secondary metabolite is synthesized by a multi-protein machinery, mainly composed of non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) enzymes. In order to decipher the fu …

PubMed
4/8 Dietas onívoras com carne e ultraprocessados aumentam E. coli pks+ no intestino, promovendo disbiose. 😷 Já dietas veganas, ricas em fibras, favorecem bactérias benéficas como bifidobactérias, reduzindo a produção de colibactina. 🌾 #MicrobiomaSaudável https://www.nature.com/articles/ejcn2011141
https://www.nature.com/articles/s41598-020-61192-y
A vegan or vegetarian diet substantially alters the human colonic faecal microbiota - European Journal of Clinical Nutrition

Consisting of ∼1014 microbial cells, the intestinal microbiota represents the largest and the most complex microbial community inhabiting the human body. However, the influence of regular diets on the microbiota is widely unknown. We examined faecal samples of vegetarians (n=144), vegans (n=105) and an equal number of control subjects consuming ordinary omnivorous diet who were matched for age and gender. We used classical bacteriological isolation, identification and enumeration of the main anaerobic and aerobic bacterial genera and computed absolute and relative numbers that were compared between groups. Total counts of Bacteroides spp., Bifidobacterium spp., Escherichia coli and Enterobacteriaceae spp. were significantly lower (P=0.001, P=0.002, P=0.006 and P=0.008, respectively) in vegan samples than in controls, whereas others (E. coli biovars, Klebsiella spp., Enterobacter spp., other Enterobacteriaceae, Enterococcus spp., Lactobacillus spp., Citrobacter spp. and Clostridium spp.) were not. Subjects on a vegetarian diet ranked between vegans and controls. The total microbial count did not differ between the groups. In addition, subjects on a vegan or vegetarian diet showed significantly (P=0.0001) lower stool pH than did controls, and stool pH and counts of E. coli and Enterobacteriaceae were significantly correlated across all subgroups. Maintaining a strict vegan or vegetarian diet results in a significant shift in the microbiota while total cell numbers remain unaltered.

Nature
5/8 A colibactina causa mutações no DNA, ligadas ao câncer colorretal. 🩺 Dietas onívoras, com inflamação crônica, amplificam esse risco. Estudos mostram que veganos têm menor prevalência de câncer intestinal, graças a um microbioma protetor. 💚 #VeganismoSalvaVidas https://www.nature.com/articles/s41591-020-0908-2
https://pmc.ncbi.nlm.nih.gov/articles/PMC4420687/
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer - Nature Medicine

Identification of a DNA-damage signature induced by colibactin, a toxin expressed by some strains of Escherichia coli, is enriched in human colorectal cancers.

Nature
6/8 A ciência é clara: fibras, antioxidantes e prebióticos de uma dieta 100% vegetal diminuem E. coli pks+ e inflamação. 🥕 Isso reduz a exposição à colibactina e protege contra doenças. Escolha veganismo para prevenir, não remediar! 🩺 #SaúdeVegana https://pmc.ncbi.nlm.nih.gov/articles/PMC8153313/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11311432/
Dietary Fibre Modulates the Gut Microbiota

Dietary fibre has long been established as a nutritionally important, health-promoting food ingredient. Modern dietary practices have seen a significant reduction in fibre consumption compared with ancestral habits. This is related to the emergence ...

PubMed Central (PMC)
7/8 Veganismo não é só saúde, é compaixão. 💕 Ao evitar carne, você protege seu corpo da colibactina e poupa animais de sofrimento. Cada refeição vegana é um ato de amor por você, pelos animais e pelo planeta. 🌍 Ser vegano é para todos! Feijão, arroz, lentilha, batata e verduras são baratos e nutritivos. 🥔 Esses alimentos ricos em fibras combatem a colibactina e promovem saúde. Veganismo pobre é saudável e sustentável! 💪 #VeganismoPopular #VeganismoÉtico https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063277
Vegetable Cost Metrics Show That Potatoes and Beans Provide Most Nutrients Per Penny

Vegetables are important sources of dietary fiber, vitamins and minerals in the diets of children. The United States Department of Agriculture (USDA) National School Lunch Program has new requirements for weekly servings of vegetable subgroups as well as beans and peas. This study estimated the cost impact of meeting the USDA requirements using 2008 national prices for 98 vegetables, fresh, frozen, and canned. Food costs were calculated per 100 grams, per 100 calories, and per edible cup. Rank 6 score, a nutrient density measure was based on six nutrients: dietary fiber; potassium; magnesium; and vitamins A, C, and K. Individual nutrient costs were measured as the monetary cost of 10% daily value of each nutrient per cup equivalent. ANOVAs with post hoc tests showed that beans and starchy vegetables, including white potatoes, were cheaper per 100 calories than were dark-green and deep-yellow vegetables. Fresh, frozen, and canned vegetables had similar nutrient profiles and provided comparable nutritional value. However, less than half (n = 46) of the 98 vegetables listed by the USDA were were consumed >5 times by children and adolescents in the 2003–4 National Health and Nutrition Examination Survey database. For the more frequently consumed vegetables, potatoes and beans were the lowest-cost sources of potassium and fiber. These new metrics of affordable nutrition can help food service and health professionals identify those vegetable subgroups in the school lunch that provide the best nutritional value per penny.

8/8 Escolher veganismo é investir no seu futuro: menos colibactina, menos câncer, mais saúde. 🌱 É também um presente para os animais e o meio ambiente. A ciência apoia: uma dieta vegetal é a chave para um mundo melhor. 🚀 A colibactina mostra como dieta afeta sua saúde até no DNA. 🧬 Seja vegano: proteja seu corpo, os animais e o planeta. Comece hoje com uma refeição simples e vegetal! 🌽 Compartilhe essa thread e espalhe a verdade vegana! 💚 #VidaVegana #VeganismoÉCiência