« Do not try and use a Python virtual environment from one Python installation or version with mod_wsgi, when mod_wsgi was compiled for a different one. »
https://modwsgi.readthedocs.io/en/develop/user-guides/virtual-environments.html#virtual-environment-and-python-version

C'est génial #virtualenv avec #Python, mais #mod_wsgi te remet direct les pieds sur terre.