#Treatment #efficacy of #cidofovir & #brincidofovir vs clade II #mpox virus isolates, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002043?via%3Dihub

Cidofovir & brincidofovir display broad-spectrum #antiviral activity vs MPXV clades I, IIa, and IIb in vitro. Systemic administration of active compound cidofovir prevents MPXV replication in mouse #respiratory tract. Oral treatment with brincidofovir limits viral replication in vivo vs a non-lethal MPXV clade IIb challenge.