dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
@egonw Could you specify your proficiency in this field? You quote Wikipedia and at the same time ask odly specific questions.
Regulation of gene expression is part of the basics of molecular biology. So a sufficiently recent book should give you a good overview on the topic.
@waldi I am contributor to @wikipathways but not proficient in the regulation mechanisms and biological importance of having so many (H4) encoding genes
Basic text books won't cover this, I think, not beyond the role of histones itself and their role in (downstream) regulation.
A recent review into the 15 encoding genes, where they are expressed, organ differences, etc, that I am hoping for a nice write up about
Egon Willighagen
waldi