@evan I'm a qualified no.

No: Mainly because this would take away any ability of non-admins to fact check/correct misinformation.

Qualified:A mechanism to flag a reply as abuse to be escalated to instance moderation would be helpful in some cases.

I consider my toots public. I do feel a responsibility to "tend to" the replies, but I don't think that includes pruning them.

It's a different story on my own domain (e.g. blog) though, because I'm responsible for all content there.