“2 random pills” and shoebox pill. Take the shoebox pill, and get a shoebox filled with the 2 random pills (since you got one they became “real”).

If you don’t want to collapse civilization or piss gasoline:

• Shoebox + any question = practically unlimited questions. Plus the first one should be something like “how can I achieve maximum happiness (in an easy way where current me would be comfortable with the results)?” and you can ask variations to get a clearer answer since you have practically unlimited ones. Only drawback is if “single-use” really means the duplicates don’t do anything.

• Shoebox + groundhog day = probably get to live >10000 years (unless “single-use” prevents that)

• Shoebox + pi money = practically unlimited money, no “single use” issue

• Shoebox + kill one person = Death Note