Oliver BarnstedtExcited to say that our paper on #hippocampus-accumbens projection #neurons and their role in spatial reward navigation and appetitive behaviours is now published in @naturecomms :
https://www.nature.com/articles/s41467-024-47361-x
Please see preprint thread for our main findings: https://neuromatch.social/@obarnstedt/110026426575610133
In addition to what we’ve shown in our preprint, we now also show that optogenetic silencing of the dorsal hippocampus-accumbens pathway leads to reduced appetitive licking near the reward zone. Plus, a lot more analysis and statistics in the supplement!
We are now also sharing all our calcium trace and behavioural data with the community: https://zenodo.org/doi/10.5281/zenodo.10698564, along with Jupyter notebooks reproducing all our main figures based on this data: https://github.com/obarnstedt/dHPC-NAc – please write me if you have any questions or queries!
This was a massive team effort with huge help from my supervisor
Stefan Remy, my fantastic colleague @petra_moce, and feedback and encouragement from many friends and colleagues (esp. [email protected]) that have helped carry this through a pandemic, paternity leave, and a lab move.
A hippocampus-accumbens code guides goal-directed appetitive behavior - Nature Communications
The dorsal hippocampus plays an important role for spatial memory, but how its outputs guide behavior is not fully understood. Here, the authors show that nucleus accumbens-specific hippocampal projection neurons carry a highly conjunctive code of spatial and action information that directs spatial reward memory-guided appetitive behaviors.
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