I rewatched recently and while there is a lot that’s dated as hell the show in general does hold up

The whole show outside of the barely plausible medical drama is about how awful House is as a human.

At every opportunity they go out of their way to spell out how horrible he is. He’s an egomaniacal drug addict with daddy issues and a borderline pedophile.

The most fun thing watching the show is counting the number of crimes he commits an episode.

I haven’t seen all the episodes but I think the underlying point was he is an asshole with actual good intentions underneath. Like he doesn’t care about the BS of being friendly, he just wants to get down to business of helping people.