Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19

This randomized study examines the effect of higher-dose fluvoxamine on time to sustained recovery from mild to moderate COVID-19 or progression to severe disease in nonhospitalized adults.

''Findings In this platform randomized clinical trial with 1175 US participants enrolled during the time that Omicron COVID-19 subvariants were circulating, there was no reportable difference in the time to sustained recovery between fluvoxamine and placebo groups (adjusted hazard ratio, 0.99 [95% credible interval, 0.89-1.09]; P for efficacy = .40). Median time to sustained recovery was 10 days (95% CI, 10-11) in both the intervention and placebo group.'