The Picard ManeuverSeek relief
ššø š šŖ šŖ šµ š± šŖšExcuse me I would rather not build up resistance to painkillers and then be screwed once I REALLY need painkillers.
The headache sucks, but itās not wisdom tooth level pain
enkiThereās a VERY big difference between āpain relieversā, NSAIDs, and āpain killersā which are opioids. NSAIDs are effective and safe if used properly.
Absolutely, the risks of addiction are monumentally different and should not be conflate. That said, my sister definitely did get addicted to Advil in her teens. On the other hand, I havenāt had an Advil in over ten years and in that time have only experienced a handful of headaches, each only lasting a few minutes. Chances are, Iām just very lucky. But thereās also a good chance that if I resorted to Advil before meditation and hydration, my luck would run out more frequently. YMMV.
Just like anything, they should be used according to directions and in moderation. I rarely take them as well, but they are safe and effective when used as directed or prescribed by your doctor.
ZagorathNot all pain killers fit into those two categories.
The normal headache pill, paracetamol (most notably sold as āPanadolā), is neither NSAID nor opioid.
Thatās Tylenol (acetaminophen) for the US folks.
Oh yeah, thatās right. Thatās a weird one. Not sure why they have two such different names.
Itās para-~a~cet~yl-~am~ino-phen~ol vs ~para-~acet~yl-~amino-phen~ol.~
Oh neat. Thanks!
Very cool way of getting across the information, too!
Flying SquidSo basically, scientists suck at coming up with shortened names everyone can agree on.
Your distinction is correct, but I simply listed NSAIDs as an example, not an exhaustive list of pain relievers. You also make assumptions on āthe normal headache pillā based on your locale. In the US paracetamol/acetaminophen/Tylenol is very common, but so is ibuprofen/Advil, naproxen sodium/Aleve, and aspirin/Bayer. In fact, Iād argue ibuprofen is far more popular here based on how much larger the ibuprofen section is compared to acetaminophen in pharmacies. Granted acetaminophen is a bit more common in compound OTC meds like cold and flu medicines.
That being said, paracetamol functions extremely similarly to NSAIDs, but itās not anti-inflammatory, and works on the nervous system only, whereas NSAIDs affect the brain and body as well.
So much medical misinformation in this thread but it looks like thereās some merit to acetaminophen tolerance.
Less so NSAIDs. They definitely need more studies that take human populations into account because there arenāt any I could find that werenāt in rats.
Regarding acetaminophen resistance: pubmed.ncbi.nlm.nih.gov/18468992/
Less so NSAIDs.
Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes - PubMed
Treatment with hepatotoxicants such as acetaminophen (APAP) causes resistance to a second, higher dose of the same toxicant (autoprotection). APAP induces hepatic mRNA and protein levels of the multidrug resistance-associated proteins (Mrp) transporters in mice and humans. Basolateral efflux transpo ā¦
Not sure why you were downvoted, this a quality comment with academic sources.
Because the people using Lemmy are no better than the people using Reddit lol.
AKA my personal experience always beats science. Even if itās placebo or nocebo. Also unless youāve already beat that vote threshold when initially posting, itās hard to turn it back. And if youāre posting something contrarian to whatās already upvoted despite it being misleading or false, then chances are whoeverās agreeing are going to be reading it more than the people disagreeing.
In circumstances like there, there are some very rare cases that donāt apply to 99.999% of the population, but it DOES apply to them. Biology be fucked like that. However you could never have a conversation on the internet if all you did was cite exceptions or anticipate personal anecdotes lol.