Seek relief
Seek relief
My friend works out and takes pain meds frequently.
He also complains about yearly kidney stones.
I have never had a kidney stone. Where he’s on his 8th one.
Was he on narcotics? I’m finding no link between Acetaminophen or Ibuprofen to kidney stones.
pubmed.ncbi.nlm.nih.gov/30829133/
Ibuprofen is mostly processed by your liver as well. Acetaminophen uses a bit of both.
This appears to occur predominantly systemically in the liver [1,10], but may occur pre-systemically in the gut as well [11]. Ibuprofen is almost completely metabolized, with little to no unchanged drug found in the urine [1,9,12].
www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/
Acetaminophen (APAP) is normally metabolized in the liver and kidney by P450 enzymes. No toxicity is observed with therapeutic doses of APAP.
The association between a history of kidney stones and current narcotic use suggests that nephrolithiasis may be a risk factor for long-term opioid use. While this study is limited by the cross-sectional design and the absence of detailed stone histories, it adds to the evidence that altering pain m …
and it’s taxing on the kidneys/liver
I hear you, I can only pretty much take acetaminophen… And yeah, it won’t pay off well.
The pain is stressing your cardiovascular system and will shorten your life. You’re also taking your suffering out on us and it’s not really fair tbh.
It’s almost guaranteed that it’s mainly because of dehydration. SO MANY people these days are constantly dehydrated (myself included, though I’m trying) because they’re drinking nothing but sodas, coffees and teas.
If everyone could drink at least 2 liters of water a day, they’d feel much better.
I was going to say 2 liters is a lot… But then I converted into funny units and it’s pretty close to what I drink on the average day (sometimes twice that, sometimes half).
Maybe also contributing to my lack of kidney stones?
Excuse me I would rather not build up resistance to painkillers and then be screwed once I REALLY need painkillers.
The headache sucks, but it’s not wisdom tooth level pain
Not all pain killers fit into those two categories.
The normal headache pill, paracetamol (most notably sold as “Panadol”), is neither NSAID nor opioid.
Oh neat. Thanks!
Very cool way of getting across the information, too!
Your distinction is correct, but I simply listed NSAIDs as an example, not an exhaustive list of pain relievers. You also make assumptions on “the normal headache pill” based on your locale. In the US paracetamol/acetaminophen/Tylenol is very common, but so is ibuprofen/Advil, naproxen sodium/Aleve, and aspirin/Bayer. In fact, I’d argue ibuprofen is far more popular here based on how much larger the ibuprofen section is compared to acetaminophen in pharmacies. Granted acetaminophen is a bit more common in compound OTC meds like cold and flu medicines.
That being said, paracetamol functions extremely similarly to NSAIDs, but it’s not anti-inflammatory, and works on the nervous system only, whereas NSAIDs affect the brain and body as well.
So much medical misinformation in this thread but it looks like there’s some merit to acetaminophen tolerance.
Less so NSAIDs. They definitely need more studies that take human populations into account because there aren’t any I could find that weren’t in rats.
Regarding acetaminophen resistance: pubmed.ncbi.nlm.nih.gov/18468992/
Less so NSAIDs.
Treatment with hepatotoxicants such as acetaminophen (APAP) causes resistance to a second, higher dose of the same toxicant (autoprotection). APAP induces hepatic mRNA and protein levels of the multidrug resistance-associated proteins (Mrp) transporters in mice and humans. Basolateral efflux transpo …
Because the people using Lemmy are no better than the people using Reddit lol.
AKA my personal experience always beats science. Even if it’s placebo or nocebo. Also unless you’ve already beat that vote threshold when initially posting, it’s hard to turn it back. And if you’re posting something contrarian to what’s already upvoted despite it being misleading or false, then chances are whoever’s agreeing are going to be reading it more than the people disagreeing.
In circumstances like there, there are some very rare cases that don’t apply to 99.999% of the population, but it DOES apply to them. Biology be fucked like that. However you could never have a conversation on the internet if all you did was cite exceptions or anticipate personal anecdotes lol.
Shouldn’t that make you sick for longer because your body can’t fight as well?
Short answer: It’s not necessarily true for most over the counter medication, with some exceptions.
Your body should have no trouble creating antibodies to fight off the infection because those drugs don’t act on white blood cells. And at around the three-to-four-day mark, the infection is almost guaranteed to go away on its own when the adaptive immune response kicks in.
Interestingly enough, most of the cold symptoms (except for fever) are part of the viral strategy to help it spread. In a weird way, the infectious agent kicks up your primary immune response to do its bidding.
What’s not recommended are fever-reducing medications. This is because elevating body temperature is your body’s way of reducing growth rates of most microorganisms and also speed up its own attack and alerts its own defenses. Reducing that temperature has a chance of increasing viral shedding. Ironically enough, this list of antipyrietic drugs includes Aspirin and paracetamol which are also used for pain relief. lol
My personal take is that it doesn’t matter much unless you’re overly concerned about being sick for–I’m guessing–half a day to a day longer with subsiding symptoms, and are overly worried about increasing the average rates of infections by a marginal amount.
(Full disclosure: I’m not a medical doctor but a former pharmacologist.)
have you tried different kinds? apparently it really varies what the standard pain reliever is depending on where you go, i believe what i’ve always taken is ibuprofen here in sweden and that is basically a miracle pill that dissolves any sort of pain and cold symptoms within half an hour for me.
however do remember to not mix different pills.
however do remember to not mix different pills.
What? Whenever I’ve needed pain relief enough where I’ve been to the doctor, they tell me to use both ibuprofen and paracetamil, as they have different active ingredients, and thus perfectly fine. They stress very much to not take too much of one at a time though.
… but not too often.
If you have regular headaches, see a doctor. Could be hay fever or other allergies for example and there’s stuff that works much better for that than painkillers.
You must be on a preventative, right? Rather than just managing pain when they come on?
I’ve tried Nurtec, Aimovig, and about to start Ajovy.
Nurtec and Aimovig worked pretty well, though not perfect. If you haven’t tried a preventative, I highly suggest seeing a neurologist, if you can.
My medication is just for managing the pain/alleviating symptoms. I have seen neurologists and have been thoroughly examined.
My migraines are caused by having received multiple traumatic brain injuries due to blunt force trauma and concussive shock waves from being blown up while deployed overseas in active combat. Unfortunately, nothing much can be done about this accept for trying to manage the pain.
The good news is that I seem to be getting them much less frequently than I used to, so maybe my brain is attempting to heal itself. I used to get a migraine just about once a week. Now it’s only about once every other month.