@slothrop I once applied for (and got!) a job where I had 100% of the qualifications they were looking for - it was a great deal... for them. For me, I was stuck in a job with very little ability to grow, and truly hated it.

Conversely, I left that job because I got offered a job I had applied for where I knew it was a stretch, but I thought I could do the role. I remember telling my wife that I had just applied for a dream job that I was in no way qualified for. I got the job, and have been here for nearly 5 years. Best job I've ever had.

Moral of the story - not only should you throw your hat in the ring in instances where you don't have all the qualifications, be wary of applying for jobs that are a way better deal for the employer than for you.