I'm with you on the transporters, but the fly in the ointment for me has always been inertial dampeners. If it's possible to sidestep conservation of inertia, I'd be pretty surprised. If not, the crew will be converted into stew the first time a ship slows down or makes a course correction.

The other part of that is, of course, that they don't seem to use the technology (or artificial gravity or the tractor beams for that matter) for anything else. In particular no weapons or defence systems.