J.H.Noyes1)Enveloped virions are the OG #LipidNanoparticles. Under ideal conditions, lipid nanoparticles < 100nm pass through the kidneys into the urine. Those larger than 100nm can get trapped in the tissues of the kidney. #KidneyDisease --structural damage and/or inflammation--further reduces the efficiency of the kidney, and presumably this reduces the size of LNPs that can be excreted through urine.
2)SARS-CoV-2 virions range from 60nm-140nm, with the majority falling somewhere between 80-120nm. After NABs denature the S-protein, larger virions will accrue in the tissues of the kidneys. Local titers of C1-INH, C4BP, and Factor H will eventually be depleted resulting in dysregulated MAC deposition and ultimately lytic activation of the SARS-like inflammatory payload, the NP-native consensus motif #TGPEAXLPY.