This says more about me than mastodon, but at this point in my life, when I'm tempted to reply to someone to disagree, I just unfollow them instead. It's better for my mental health.
@fraying Most of my Mastodon feed and replies are lovely. Of course, there will be exceptions. Any time I'm tempted to argue with someone, I just unfollow and/or block them instead.
Friendly disagreements about silly stuff (pineapple pizza, for example) are diversions; someone thinking social media doesn't need moderation is something else entirely.