The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation

Multiple sclerosis is a T cell-driven autoimmune disease that is linked to both gut flora and external environmental factors. This study shows that deleting the aryl hydrocarbon receptor (a sensor for the gut microbiota) in T lymphocytes triggers a change in intestinal bile acids and short chain fatty acids, which appear to protect against multiple sclerosis.