I'm having like, an ongoing panic attack as I'm collating and compiling Brain & COVID research articles together.
Like chemobrain in some ways,
Like HIV associated neurocognitive decline in some ways,
Like Parkinson's in some ways,
Like Alzheimer's in some ways,
Like accelerated aging in some ways,
Like stroke in many ways,
AVOID.
COVID.
FOR FUCKS SAKE.
@hannu_ikonen But unlike all of the above in one very important facet: response.
We respond to it, from a policy perspective, like it's significantly less concerning than the flu.
@hannu_ikonen Back when COVID was new, someone infected some monkeys and then dissected them. All of the monkeys had Lewy bodies in their brains, post-infection. https://www.biorxiv.org/content/10.1101/2021.02.23.432474v2
I keep wondering if someone has checked humans for that particular consequence.
@dangit
This is a good question, no apologies necessary.
This is a summary of a study that discusses how covid can cause immune responses that attack your own cells https://med.stanford.edu/news/all-news/2021/09/covid-19-autoantibodies.html
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This virus affects the respiratory tract and usually leads to pneumonia in most patients and acute respiratory distress syndrome (ARDS) in 15% of cases. ARDS is one of the leading causes of death in patients with COVID-19 and is mainly triggered by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins, such as interleukin-6 (1L-6), interleukin-1 (IL-1), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) play a very significant role in lung damage in ARDS patients through the impairments of the respiratory epithelium. Cytokine storm is defined as acute overproduction and uncontrolled release of pro-inflammatory markers, both locally and systemically. The eradication of COVID-19 is currently practically impossible, and there is no specific treatment for critically ill patients with COVID-19; however, suppressing the inflammatory response may be a possible strategy. In light of this, we review the efficacy of specific inhibitors of IL6, IL1, IL-17, and TNF-α for treating COVID-19-related infections to manage COVID-19 and improve the survival rate for patients suffering from severe conditions. Graphical Abstract
@dangit
More recent studies have revealed that it's worse than unregulated cytokine response: under some conditions your immune system begins producing antibodies that attack your own cells, too
https://magazine.ucsf.edu/your-immune-system-could-turn-covid-19-deadly
@dangit
This article discusses a related phenomenon called 'immune amnesia' whereby measles in particular exhausts and resets your immune system, causing it to 'forget' how to protect you from diseases you had immunity from (whether by surviving it, or being vaccinated for it)
@dangit
Rest well.
The bad news is that there's sooooo much more
for example, covid has been shown (like chicken pox) to permeate the blood-brain barrier, which means it could potentially (as chicken pox does) be resident there and recur with old age (as c.p. does, as 'shingles').
It's a novel virus, we're going to discover all sorts of new nightmares about this one- and for that matter, science is discovering a lot about how immunity works that complicates the old models.
Covid hasn't caught me yet and I'll keep wearing a mask.
Doing my brst, but nobody's helping.
Hannu Ikonen, MD
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