Note that OneDrive is actually pretty good now. (Yes, it was fucking garbage, I lived it every day, I know.) If your org is having consistent problems:

- Install OneDrive machine-wide with the installer switch, get binaries and maintenance tasks out of user profile
- Check your registry for weird old GroupPolicy still being applied
- Review and apply latest GroupPolicy settings
- If you use a proxy, make sure you're on latest vendor recommended exclusions. Call them and ask for a health check. We just did one and it found issues with our O365 settings.

We have largely moved users to OneDrive for business content and also selectively doing Desktop/Documents backup.

If your company uses Office365, your most important ransomware insurance is getting your user files on OneDrive. And it can transparently backup Desktop/Documents now, users don't need to put stuff in OneDrive manually if you manage the setting with GroupPolicy.
@SwiftOnSecurity I don't think there's anything transparent about how it picks up and moves your entire documents/desktop folders into the onedrive folder without even warning you that's how it'll do things when you turn it on.
Better hope you didn't have anything that uses fixed file paths stored there or it's now busted!