Note that OneDrive is actually pretty good now. (Yes, it was fucking garbage, I lived it every day, I know.) If your org is having consistent problems:

- Install OneDrive machine-wide with the installer switch, get binaries and maintenance tasks out of user profile
- Check your registry for weird old GroupPolicy still being applied
- Review and apply latest GroupPolicy settings
- If you use a proxy, make sure you're on latest vendor recommended exclusions. Call them and ask for a health check. We just did one and it found issues with our O365 settings.

We have largely moved users to OneDrive for business content and also selectively doing Desktop/Documents backup.