The new Mastodon desktop browser client Elk.zone is pretty great. I just had to bump the tiny fonts up slightly but I'm really liking the clean Twitter-in-its-design-heyday-back-when-Doug-Bowman-still-worked-there-let's-call-it-2014ish looks
@mathowie This is promising, but I can't really live without my TweetDeck-esque view.
@rands Mastodesk promises this experience (currently in closed Beta
https://mastodeck.com)

MastoDeck - advanced Mastodon client
The ultimate Mastodon client for power users. Real-time, fully customizable, built to match how you use Mastodon.
mastodeck.com