Madison Cawthorne won't read your "haha he's in a wheelchair" joke.
Donald Trump will never see your fat joke.
Joe Biden will never hear your jokes about his stutter.
Your friends will. Your friends with mobility aids. Your friends who aren't a size 0. Your friend with a speech impediment they've worked relentlessly to overcome.
If you want to make a joke about a politician/public figure, find something worth joking about. Ableism ain't it. Weight ain't it.
Examine the engine of your humor.