PLOS BiologyBacteria-mediated #cancer therapy uses bacterial strains to colonize #tumors & deliver therapeutic molecules. This study engineers E. coli Nissle 1917 strains to make & deliver the drug #romidepsin (FK228), achieving improved efficacy & reduced systemic toxicity @PLOSBiology https://plos.io/3NadfQv
Engineered romidepsin biosynthetic pathways in Escherichia coli Nissle 1917 improve the efficacy of bacteria-mediated cancer therapy
Bacteria-mediated cancer therapy exploits the ability of bacterial strains to specifically colonize tumors and deliver therapeutic molecules. This study engineers Escherichia coli Nissle 1917 strains to biosynthesize and deliver the anticancer drug romidepsin, achieving improved intratumoral efficacy and reduced systemic toxicity in tumor models.