CharrveinContrary to ... expectations, evolution experiments with microbes recurrently show that the early stages of adaptation often proceed via large-effect, highly pleiotropic mutations [4,5].
Cool paper
#plos #plosbiology #regevolution #pleiotropy #nettwork evolution
Https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002922
Regulatory networks may evolve to favor adaptive foresight
Pleiotropy (a single mutation altering many traits) has long been seen as hindering adaptation. A new study in PLOS Biology offers a striking counterexample, suggesting that regulatory networks may evolve to ensure mutations are simultaneously beneficial in correlated environments.