Slidedeck from an internal presentation on diabetic kidney disease 👇
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on #Kidney Disease in people with #diabetes #flozin #sglt2i #MRA #GLP1RA
#MedEd #MedMastodon #NephMastodon
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on Kidney Disease in people with diabetes - Download as a PDF or view online for free
From 2008: compensation formulas in respiratory acid base disorders. Source data in ref 3 (from 1998). The uncertainty of the formulas (standard error is 5mM) is underappreciated in clinical practice (1 kPa = 7.5 mmHg) & we end up hunting for zebras.
https://thorax.bmj.com/content/63/3/289
Respiratory acidosis and alkalosis are associated with compensatory physiological changes, including extracellular and intracellular buffering, and altered renal ion handling. In clinical practice, mixed acid-base disturbances may be misdiagnosed if the expected magnitude of compensation for a primary respiratory disorder is not known. The ability to assess physiological compensation rapidly for acid-base disorders can be achieved either through intuition gained after many years of clinical experience, by use of a graph or nomogram,1 or through the application of one of the published formulae for predicting compensation.2 3 However, nomograms are often not readily available in clinical environments, and the most accurate formulae are complex and difficult to memorise reliably. A comprehensive summary of previously published measurements of metabolic compensation …
Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022
buff.ly/3OV4KUY (FREE) #FOAMed #NephMastodon
Our #Nephrology #fellowship program webpage at #UNM #UNMHSC has been updated (kudos to @nephcrit_nm our PD who brought the project to completion!).
Surf the wave to see what we offer for subspecialty training in Nephrology 👇
https://hsc.unm.edu/medicine/departments/internal-medicine/academic-divisions/nephrology/fellowship.html
Fresh from the press, my most recent collaboration about
Pseudohyponatremia: Mechanism, Diagnosis, Clinical Associations and Management https://www.mdpi.com/2344126 #mdpijcm via @JCM_MDPI
@MRoumelioti
#NephMastodon
Pseudohyponatremia remains a problem for clinical laboratories. In this study, we analyzed the mechanisms, diagnosis, clinical consequences, and conditions associated with pseudohyponatremia, and future developments for its elimination. The two methods involved assess the serum sodium concentration ([Na]S) using sodium ion-specific electrodes: (a) a direct ion-specific electrode (ISE), and (b) an indirect ISE. A direct ISE does not require dilution of a sample prior to its measurement, whereas an indirect ISE needs pre-measurement sample dilution. [Na]S measurements using an indirect ISE are influenced by abnormal concentrations of serum proteins or lipids. Pseudohyponatremia occurs when the [Na]S is measured with an indirect ISE and the serum solid content concentrations are elevated, resulting in reciprocal depressions in serum water and [Na]S values. Pseudonormonatremia or pseudohypernatremia are encountered in hypoproteinemic patients who have a decreased plasma solids content. Three mechanisms are responsible for pseudohyponatremia: (a) a reduction in the [Na]S due to lower serum water and sodium concentrations, the electrolyte exclusion effect; (b) an increase in the measured sample’s water concentration post-dilution to a greater extent when compared to normal serum, lowering the [Na] in this sample; (c) when serum hyperviscosity reduces serum delivery to the device that apportions serum and diluent. Patients with pseudohyponatremia and a normal [Na]S do not develop water movement across cell membranes and clinical manifestations of hypotonic hyponatremia. Pseudohyponatremia does not require treatment to address the [Na]S, making any inadvertent correction treatment potentially detrimental.
Sesordle 13 6/8
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#meded
Woohoo! I'm still having trouble with words that have the same consecutive letter, but this time I took a chance and hit the jackpot!
https://akshar727.itch.io/sesordle (coded by my son)
#MedEd #medicine #MedMastodon #nephTwitter #nephmastodon #nephpearls #cardioed #cardiotwitter
Sesordle 7 6/8
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My son has created this game for anyone who would like to play (free). He has added extra features to make it more enjoyable.
Find it at https://akshar727.itch.io/sesordle
#NephTwitter #cardioed #CardioTwitter #medicine #medtwitter #MedMastodon #nephmastodon #nephpearls #nephbeans
Sesordle 6 4/8
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This game was created by little boy.
Screenshot of the game interface is attached.
If you'd like to play Sesordle (Mac OS only), download it here.
Tejas
https://akshar727.itch.io/sesordle
#NephTwitter #cardioed #CardioTwitter #medicine #medtwitter #MedMastodon #nephmastodon #nephpearls #nephbeans
Christos Argyropoulos MD, PhD
Tejas Desai, MD ☑️